Numerical Simulation of Microflows with Moment Method

This paper was presented at the 4th Micro and Nano Flows Conference (MNF2014), which was held at University College, London, UK. The conference was organised by Brunel University and supported by the Italian Union of Thermofluiddynamics, IPEM, the Process Intensification Network, the Institution of Mechanical Engineers, the Heat Transfer Society, HEXAG - the Heat Exchange Action Group, and the Energy Institute, ASME Press, LCN London Centre for Nanotechnology, UCL University College London, UCL Engineering, the International NanoScience Community, www.nanopaprika.eu.A series of hyperbolic moment equations is derived for the Boltzmann equation with ES-BGK collision term. These systems can be obtained through a slight modification in the deduction of Grad’s moment equations, and such a method is suitable for deriving systems with moments up to any order. The systems are equipped with proper wall boundary conditions so that the number of equations in the boundary conditions is consistent with the hyperbolic structure of the moment system. Our numerical scheme for solving the hyperbolic moment systems is of second order, and a special mapping method is introduced so that the numerical efficiency is highly enhanced. Our numerical results are validated by comparison with the DSMC results. Through the numerical solutions of systems with increasing number of moments, the convergence of the moment method is clearly observed

A novel insight of sentinel lymph node concept based on 1-3 positive nodes in patients with pT1-2 gastric cancer

<p>Abstract</p> <p>Background</p> <p>Sentinel node (SN) biopsy has been practiced in gastric cancer in recent years, and many studies focused on the distribution of solitary lymph node metastasis (SLM) to assess the pattern of SN. In fact, there is usually more than one SN existing in gastric cancer. The distribution of SNs needs to be further re-evaluated.</p> <p>Methods</p> <p>A total of 289 patients in pT1-2 stage with 1-3 positive nodes confined to same compartment were included in this study with informed consents. The primary lesion was solitary (≤ 5.0 cm in diameter) and D2 or D3 lymph node dissection had been performed. The location of metastatic lymph nodes was analyzed retrospectively.</p> <p>Results</p> <p>Most positive nodes occurred in N1 compartment, with frequency of 79.6% to 85.7% based on site of tumor. In the lower third of stomach, no. 6 was the most common metastatic site and no. 3 was the second; the order was reversed for SLM. With increasing depth of tumor invasion, a progressively augmented nodal involvement was shown. Nearly a half appeared transverse metastasis when the tumor located at the lesser or greater curvature. Among skip metastasis, no. 7, 8a, 9 and 11p were the most common metastatic sites and the prognosis was as similar as that of patients with N1 involved only.</p> <p>Conclusions</p> <p>The 1-3 positive nodes in the same compartment should be possible SNs, and most of which are restricted in N1 in pT1-2 gastric cancer. Transversal and 2 stations lymph node metastasis are common.</p

A dual AAV system enables the Cas9-mediated correction of a metabolic liver disease in newborn mice

Many genetic liver diseases present in newborns with repeated, often lethal, metabolic crises. Gene therapy using non-integrating viruses such as AAV is not optimal in this setting because the non-integrating genome is lost as developing hepatocytes proliferate1,2. We reasoned that newborn liver may be an ideal setting for AAV-mediated gene correction using CRISPR/Cas9. Here we intravenously infuse two AAVs, one expressing Cas9 and the other expressing a guide RNA and the donor DNA, into newborn mice with a partial deficiency in the urea cycle disorder enzyme, ornithine transcarbamylase (OTC). This resulted in reversion of the mutation in 10% (6.7% – 20.1%) of hepatocytes and increased survival in mice challenged with a high-protein diet, which exacerbates disease. Gene correction in adult OTC-deficient mice was lower and accompanied by larger deletions that ablated residual expression from the endogenous OTC gene, leading to diminished protein tolerance and lethal hyperammonemia on a chow diet

On Uplink Interference Scenarios in Two-Tier Macro and Femto Co-Existing UMTS Networks

A two-tier UMTS network is considered where a large number of randomly deployed Wideband Code Division Multiple Access (WCDMA) femtocells are laid under macrocells where the spectrum is shared. The cochannel interference between the cells may be a potential limiting factor for the system. We study the uplink of this hybrid network and identify the critical scenarios that give rise to substantial interference. The mechanism for generating the interference is analyzed and guidelines for interference mitigation are provided. The impacts of the cross-tier interference especially caused by increased numbers of users and higher data rates are evaluated in the multicell simulation environment in terms of the noise rise at the base stations, the cell throughput, and the user transmit power consumption

Minimising Complexity in Iterative Multiuser Detection using Dynamic Decoding Schedules

In this paper we utilize extrinsic information transfer (EXIT) chart analysis with unequal user power levels in a coded directsequence code-division multiple-access (DS-CDMA) multiuser receiver to derive a dynamic decoding schedule. Conventional receivers generally follow a static predetermined decoding schedule. However, decoding delay and complexity can be significantly reduced while maintaining BER performance through a dynamic decoding schedule optimized for a given load and transmit power configuration. Verified through simulations, we show that complexity savings of up to 5000 can be achieved. We also derive the effective EXIT charts which can be used for the convergence analysis and performance predictions of unequal power CDMA systems